Control-matched octo/nonagenarian outcomes in acute basilar artery occlusions treated with mechanical thrombectomy-analysis of the PC-SEARCH thrombectomy registry.
Publication/Presentation Date
7-23-2024
Abstract
INTRODUCTION: Age is often used as a predictor in determining outcomes in large vessel occlusions treated with mechanical thrombectomy. However, limited data exist for octo/nonagenarian outcomes compared to younger individuals in acute basilar artery occlusions treated with thrombectomy.
METHODS: Patient data were obtained from the PC-SEARCH Thrombectomy Registry which consists of 444 acute basilar artery occlusions treated with mechanical thrombectomy. Individuals were dichotomized based on age (>80 and ≤80 years old). Primary outcome was defined as modified Rankin Scale of 0-3 at 90 days. Logistic and multivariate regression, as well as control-matched analysis, were performed.
RESULTS: There were 373 and 71 patients in the younger and older cohorts, respectively. Gender, ethnicity, smoking status, atrial fibrillation, and coronary artery disease were noted to be significantly different between cohorts. At 90 days, 178 (47.7%) and 23 (32.4%) patients achieved primary outcome at 90 days (p = 0.02), however, after controlling for potentially confounding factors this association lost significance (OR 0.50 95% CI 0.24-1.05; p = 0.07). There were 84 patients included in the control matched analysis and demonstrated no significant differences on multivariate analysis between cohorts (OR 0.68 95% CI 0.25-1.84; p = 0.45).
INTERPRETATION: Octa/nonagenarians presenting with an acute basilar artery occlusion treated with mechanical thrombectomy can achieve acceptable rates of favorable functional outcomes compared to younger individuals with similar baseline demographic and stroke characteristics.
First Page
15910199241265397
Last Page
15910199241265397
ISSN
2385-2011
Published In/Presented At
Mierzwa, A. T., Prologo-Richardson, P., Kasab, S. A., Nelson, A., Gutierrez, S. O., Vivanco-Suarez, J., Farooqui, M., Jadhav, A. P., Desai, S., Toth, G., Alrohimi, A., Nguyen, T. N., Klein, P., Abdalkader, M., Salahuddin, H., Wilseck, Z., Pandey, A., Koduri, S., Vora, N., Aladamat, N., … Jumaa, M. (2024). Control-matched octo/nonagenarian outcomes in acute basilar artery occlusions treated with mechanical thrombectomy-analysis of the PC-SEARCH thrombectomy registry. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 15910199241265397. Advance online publication. https://doi.org/10.1177/15910199241265397
Disciplines
Medicine and Health Sciences
PubMedID
39043366
Department(s)
Department of Surgery
Document Type
Article