Oral methadone therapy is an effective and increasingly popular treatment for opioid dependency and chronic pain. Although it is not typically considered pro-dysrhythmic, we present the unique case of a 52-year-old HIV-positive woman without underlying cardiac disease who developed QTc prolongation and pulseless Torsades secondary to high dose methadone therapy.
Published In/Presented At
Routhier DD, Katz KD, Brooks DE. QTc prolongation and torsades de pointes associated with methadone therapy. J Emerg Med. 2007 Apr;32(3):275-8. doi: 10.1016/j.jemermed.2006.07.027. Epub 2007 Feb 2.
Medicine and Health Sciences
Toxicology Division, Department of Emergency Medicine Faculty, Department of Emergency Medicine