QTc prolongation and torsades de pointes associated with methadone therapy.
Oral methadone therapy is an effective and increasingly popular treatment for opioid dependency and chronic pain. Although it is not typically considered pro-dysrhythmic, we present the unique case of a 52-year-old HIV-positive woman without underlying cardiac disease who developed QTc prolongation and pulseless Torsades secondary to high dose methadone therapy.
Published In/Presented At
Routhier DD, Katz KD, Brooks DE. QTc prolongation and torsades de pointes associated with methadone therapy. J Emerg Med. 2007 Apr;32(3):275-8. doi: 10.1016/j.jemermed.2006.07.027. Epub 2007 Feb 2.
Medicine and Health Sciences
Department of Emergency Medicine, Department of Emergency Medicine Faculty, Toxicology Division