Title

The Prevalence of Reduced Glomerular Filtration Rate in Older Hypertensive Patients and its Association with Cardiovascular Disease: a Report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

Publication/Presentation Date

5-10-2004

Abstract

BACKGROUND: The prevalence of reduced glomerular filtration rate (GFR) in older hypertensive patients and the relationship between level of GFR and cardiovascular disease (CVD) and its risk factors are not well known.

METHODS: We evaluated baseline renal function in 40 514 hypertensive patients 55 years or older who were enrolled in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). We used the simplified Modification of Diet in Renal Disease study equation to estimate GFR and examined the prevalence of CVD in patients with different levels of GFR.

RESULTS: Fifty-seven percent of patients had mild (60-89 mL/min per 1.73 m(2)), 17.2% had moderate (30-59 mL/min per 1.73 m(2)), and 0.6% had severe (

CONCLUSIONS: The prevalence of reduced GFR is high in older hypertensive patients. Patients with moderate or severe reduction in GFR are more likely to have a history of CVD and ECG-LVH. Even modest reductions in GFR are independently associated with a higher prevalence of CVD and ECG-LVH.

Volume

164

Issue

9

First Page

969

Last Page

976

ISSN

0003-9926

Disciplines

Internal Medicine | Medical Sciences | Medicine and Health Sciences | Nephrology

PubMedID

15136305

Department(s)

Department of Medicine

Document Type

Article