Title

Lactic Acidosis: A Rare Oncological Emergency in Solid Tumors at Presentation.

Publication/Presentation Date

4-1-2017

Abstract

Lactic acidosis is a potentially life-threatening complication characterized by accumulation of blood lactate resulting in low arterial pH. The majority of lactic acidosis in malignancies are reported in association with hematologic malignancies. It may result from an imbalance between lactate production and hepatic lactate utilization, but the exact pathophysiology is far more complex than what we can fathom from current micromolecular studies. We report a case of a 71-year-old male with metastatic lung cancer presenting with fatal lactic acidosis in the absence of liver involvement. Review of the literature reveals only 27 reported cases of solid tumors presenting with lactic acidosis, of which nearly all of them had extensive liver metastasis. Patients were treated with aggressive fluid resuscitation, bicarbonate administration and hemodialysis, but the only effective treatment modality was early aggressive chemotherapy initiation.

Volume

353

Issue

4

First Page

402

Last Page

406

ISSN

1538-2990

Disciplines

Hematology | Medical Sciences | Medicine and Health Sciences | Oncology

PubMedID

28317631

Department(s)

Department of Medicine, Hematology-Medical Oncology Division Fellows and Residents

Document Type

Article