Multimodality therapy for patients with high-risk prostate cancer: current status and future directions.
Publication/Presentation Date
6-1-2013
Abstract
Prostate cancer is the most commonly diagnosed cancer and second most common cause of cancer death in American men. Although high-risk disease accounts for less than 15% of diagnoses, high-risk prostate cancer patients have a cancer-specific mortality rate of 15% at 10 years. There is currently no consensus on the optimal management of high-risk disease because (1) there are different primary modalities available (ie, surgery, radiation), for which there are no randomized trials comparing efficacy; and (2) unstandardized timing of different therapies (ie, neoadjuvant v concurrent v adjuvant), which makes comparisons of efficacy problematic. Increased understanding into the mechanisms leading to the formation of advanced metastatic disease has spurred the development of agents to target these pathways. However, new questions regarding optimal management of disease arise with regard to the role of these therapies in combination with "conventional" primary modalities for earlier stage, high-risk prostate cancer patients. In this article, we review the transforming world of multimodality therapy in high-risk prostate cancer.
Volume
40
Issue
3
First Page
308
Last Page
321
ISSN
1532-8708
Published In/Presented At
Zaorsky, N. G., Trabulsi, E. J., Lin, J., & Den, R. B. (2013). Multimodality therapy for patients with high-risk prostate cancer: current status and future directions. Seminars in oncology, 40(3), 308–321. https://doi.org/10.1053/j.seminoncol.2013.04.006
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23806496
Department(s)
Administration and Leadership
Document Type
Article