Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation.

Authors

• Veda N Giri
• Elias Obeid
• Laura Gross
• Lisa Bealin
• Colette Hyatt
• Sarah E Hegarty
• Susan Montgomery
• Andrea Forman
• Ruth Bingler
• William K Kelly
• Adam P Dicker
• Stephanie Winheld
• Edouard J Trabulsi
• David Y T Chen
• Costas D Lallas
• Brian A Allen
• Mary B Daly
• Leonard G Gomella

Publication/Presentation Date

5-1-2017

Abstract

PURPOSE: Multigene panels are commercially available for the evaluation of prostate cancer (PCA) predisposition, which necessitates tailored genetic counseling (GC) for men. Here we describe emerging results of Genetic Evaluation of Men, prospective multigene testing study in PCA to inform personalized genetic counseling, with emerging implications for referrals, cancer screening, and precision therapy.

PATIENTS AND METHODS: Eligibility criteria for men affected by or at high risk for PCA encompass age, race, family history (FH), and PCA stage/grade. Detailed demographic, clinical, and FH data were obtained from participants and medical records. Multigene testing was conducted after GC. Mutation rates were summarized by eligibility criteria and compared across FH data. The 95% CI of mutation prevalence was constructed by using Poisson distribution.

RESULTS: Of 200 men enrolled, 62.5% had PCA. Eleven (5.5%; 95% CI, 3.0% to 9.9%) had mutations; 63.6% of mutations were in DNA repair genes. FH of breast cancer was significantly associated with mutation status (

CONCLUSION: Multigene testing for PCA identifies mutations mostly in DNA repair genes, with implications for precision therapy. The study highlights the importance of comprehensive genetic evaluation for PCA beyond metastatic disease, including early-stage disease with strong FH. Detailed FH is important for referrals of men for genetic evaluation. The results inform precision GC and cancer screening for men and their male and female blood relatives.

Volume

1

ISSN

2473-4284

Published In/Presented At

Giri, V. N., Obeid, E., Gross, L., Bealin, L., Hyatt, C., Hegarty, S. E., Montgomery, S., Forman, A., Bingler, R., Kelly, W. K., Dicker, A. P., Winheld, S., Trabulsi, E. J., Chen, D. Y. T., Lallas, C. D., Allen, B. A., Daly, M. B., & Gomella, L. G. (2017). Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation. JCO precision oncology, 1, PO.16.00039. https://doi.org/10.1200/PO.16.00039

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

34164591

Department(s)

Administration and Leadership

Document Type

Article