Histone deacetylases and cancer: causes and therapies.

Authors

• P Marks
• R A Rifkind
• V M Richon
• R Breslow
• T Miller
• W K Kelly

Publication/Presentation Date

12-1-2001

Abstract

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect?

Volume

1

Issue

3

First Page

194

Last Page

202

ISSN

1474-175X

Published In/Presented At

Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001). Histone deacetylases and cancer: causes and therapies. Nature reviews. Cancer, 1(3), 194–202. https://doi.org/10.1038/35106079

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

11902574

Department(s)

Administration and Leadership

Document Type

Article