Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy.
Publication/Presentation Date
5-1-2008
Abstract
PURPOSE: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease.
DESIGN: Cross-sectional study.
METHODS: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 microm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT.
RESULTS: On average, CSF thickness was 201 +/- 22 microm. CSF thickness was significantly greater in retinas from men than retinas from women (mean +/- standard deviation, 209 +/- 18 microm vs 194 +/- 23 microm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10).
CONCLUSIONS: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.
Volume
145
Issue
5
First Page
894
Last Page
901
ISSN
0002-9394
Published In/Presented At
Bressler, N. M., Edwards, A. R., Antoszyk, A. N., Beck, R. W., Browning, D. J., Ciardella, A. P., Danis, R. P., Elman, M. J., Friedman, S. M., Glassman, A. R., Gross, J. G., Li, H. K., Murtha, T. J., Stone, T. W., Sun, J. K., & Diabetic Retinopathy Clinical Research Network (2008). Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy. American journal of ophthalmology, 145(5), 894–901. https://doi.org/10.1016/j.ajo.2007.12.025
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18294608
Department(s)
Administration and Leadership
Document Type
Article