Surgical experience with pancreatic islet-cell tumors.
Publication/Presentation Date
10-1-1993
Abstract
OBJECTIVE: To review the surgical management of pancreatic islet-cell tumors, with attention to preoperative localization, surgical therapy, and postoperative survival.
DESIGN: Consecutive case series of patients treated surgically for pancreatic islet-cell tumor.
SETTING: The Johns Hopkins Hospital, a large teaching hospital in Baltimore, Md, serving both as a primary and tertiary care center.
PATIENTS: Thirty-seven patients with pancreatic islet-cell tumors treated surgically between 1979 and 1990.
MAIN OUTCOME MEASURES: Success of preoperative localization studies, types of operations performed, and postoperative survival.
RESULTS: Preoperative computed tomography correctly localized the tumor in 20 of 34 patients (59%); angiography in 21 of 28 patients (75%), and the combination of computed tomography and angiography in 23 of 28 patients (82%). Benign islet-cell tumors were found in 19 patients, and malignant tumors in 18 patients. Twenty-four patients (65%) had functional tumors. The proportion of patients with nonfunctioning tumors increased from 0% before 1984, to 43% from 1985 to 1990. Surgical therapy was curative in 27 patients and palliative in 10. The most commonly performed operative procedures were tumor enucleation (11 patients [30%]), distal pancreatectomy (10 patients [27%]). There was no operative mortality. The actuarial survival at 40 months was 100% in patients with benign tumors and significantly lower (66%) in patients with malignant tumors.
CONCLUSIONS: This experience from a single institution underscores the role of preoperative localization studies and appropriate surgical management of these rare tumors.
Volume
128
Issue
10
First Page
1143
Last Page
1148
ISSN
0004-0010
Published In/Presented At
Yeo, C. J., Wang, B. H., Anthone, G. J., & Cameron, J. L. (1993). Surgical experience with pancreatic islet-cell tumors. Archives of surgery (Chicago, Ill. : 1960), 128(10), 1143–1148. https://doi.org/10.1001/archsurg.1993.01420220063008
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8105769
Department(s)
Administration and Leadership
Document Type
Article