Human cholecystokinin-A receptor is not an oncofetal protein.
Publication/Presentation Date
3-1-2000
Abstract
The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors in human fetal, postnatal, and adult pancreas to determine whether the appearance of CCK-A receptors in pancreatic adenocarcinomas reflected oncofetal antigen or pancreatic neoantigen expression. Messenger ribonucleic acid (mRNA) was isolated from six paraffin-embedded normal pancreatic autopsy specimens ranging in age from 17 weeks postfertilization through 26 days following full-term delivery, and samples of adult human tissues, including pancreas and pancreatic adenocarcinoma. Using reverse transcription-polymerase chain reactions, CCK-B receptor mRNA was expressed in all specimens of normal fetal and postnatal human pancreas, adult pancreas, and pancreatic adenocarcinomas. CCK-A receptor mRNA was selectively expressed only in pancreatic adenocarcinomas. These data suggest that selective CCK-A receptor expression in pancreatic adenocarcinomas reflects neoantigen expression in humans.
Volume
45
Issue
3
First Page
538
Last Page
543
ISSN
0163-2116
Published In/Presented At
Weinberg, D. S., So, C., Ruggeri, B., Biswas, S., Barber, M., & Waldman, S. (2000). Human cholecystokinin-A receptor is not an oncofetal protein. Digestive diseases and sciences, 45(3), 538–543. https://doi.org/10.1023/a:1005449308536
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10749330
Department(s)
Administration and Leadership
Document Type
Article