Platelet-mediated thrombolysis in patients with δ-storage pool deficiency: a thrombelastographic analysis.
We present the first thrombelastographic descriptions of three patients with δ-storage pool deficiency, a platelet disorder that involves a deficiency of dense granules and moderate bleeding. The patients demonstrated a 49-54% loss of platelet-mediated clot strength over a 1-2-h period after normal thrombus formation. This pattern persisted, with some attenuation of loss of strength following administration of epsilon aminocaproic acid, desmopressin and platelets for tonsillectomy. Assessment of platelet function in patients with platelet granule disorders can be accomplished with thrombelastographic methods in ambulatory and perioperative settings; however, the effects of therapy for this disorder cannot be monitored with thrombelastography without obtaining a blood sample prior to prophylactic hemostatic intervention.
Published In/Presented At
Brodsky, M. A., Machovec, K. A., Chambers, B. P., & Nielsen, V. G. (2011). Platelet-mediated thrombolysis in patients with δ-storage pool deficiency: a thrombelastographic analysis. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 22(7), 610–612. https://doi.org/10.1097/MBC.0b013e328349a2a4
Anesthesiology | Medicine and Health Sciences
Department of Anesthesiology