Perfusion-Dependent Focal Neurologic Deficits in a Critically Ill Heart Transplant Recipient: A Case of Tacrolimus-Associated Reversible Cerebral Vasospasm Syndrome?
Publication/Presentation Date
4-6-2023
Abstract
TACROLIMUS, a mainstay of immunosuppression after orthotopic heart transplantation (OHT), is associated with a broad range of side effects. Vasoconstriction caused by tacrolimus has been proposed as a mechanism underlying common side effects such as hypertension and renal injury. Neurologic side effects attributed to tacrolimus include headaches, posterior reversible encephalopathy syndrome (PRES), or reversible cerebral vasospasm syndrome (RCVS). Six case reports have been published describing RCVS in the setting of tacrolimus administration after OHT. The authors report a case of perfusion-dependent focal neurologic deficits attributed to tacrolimus-induced RCVS in an OHT recipient.
ISSN
1532-8422
Published In/Presented At
Bloom, J., Collins, M. L., Belovsky, M. P., Feduska, E., Schofield, P., Leong, R., Augoustides, J. G., Lembrikov, I., Kogan, A., Frogel, J., Rajkumar, K. P., Hicks, M. H., & Fernando, R. J. (2023). Perfusion-Dependent Focal Neurologic Deficits in a Critically Ill Heart Transplant Recipient: A Case of Tacrolimus-Associated Reversible Cerebral Vasospasm Syndrome?. Journal of cardiothoracic and vascular anesthesia, S1053-0770(23)00235-5. Advance online publication. https://doi.org/10.1053/j.jvca.2023.03.044
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
37120321
Department(s)
Department of Anesthesiology
Document Type
Article