Critical Care Cardiology Trials Network (CCCTN): a cohort profile.


Thomas S Metkus, Johns Hopkins University
Vivian M Baird-Zars, Brigham and Women's HospitalFollow
Carlos E Alfonso, University of Miami
Carlos L Alviar, New York UniversityFollow
Christopher F Barnett, University of California, San FranciscoFollow
Gregory W Barsness, Mayo ClinicFollow
David D Berg, Brigham and Women's HospitalFollow
Mia Bertic, University of Toronto Etobicoke
Erin A Bohula, Brigham and Women's HospitalFollow
James Burke MD, Lehigh Valley Health NetworkFollow
Barry Burstein, University of Toronto
Sunit-Preet Chaudhry, St. Vincent Heart CenterFollow
Howard A Cooper, Westchester Medical Center and New York Medical College
Lori B Daniels, University of California - San DiegoFollow
Christopher B Fordyce, University of British ColumbiaFollow
Shahab Ghafghazi, University of Louisville
Michael Goldfarb, McGill University
Jason N Katz, Duke University
Ellen C Keeley, University of Florida
Norma M Keller, New York University
Benjamin Kenigsberg, MedStar Washington Hospital Center
Michael C Kontos, Virginia Commonwealth University
Younghoon Kwon, University of Washington
Patrick R Lawler, University of Toronto
Evan Leibner, Mount Sinai Hospital
Shuangbo Liu, Max Rady College of Medicine
Venu Menon, Cleveland Clinic Foundation
P Elliott Miller, Yale University
L Kristin Newby, Duke University
Connor G O'Brien, University of California, San Francisco
Alexander I Papolos, MedStar Washington Hospital Center
Matthew J Pierce, Zucker School of Medicine at Hofstra/Northwell
Rajnish Prasad, Wellstar Cardiovascular Medicine
Barbara Pisani, Atrium Wake Forest Baptist
Brian J Potter, Centre Hospitalier de l'Université de Montréal
Robert O Roswell, Lenox Hospital, Northwell Health
Shashank S Sinha, Inova Fairfax Medical Center
Kevin S Shah, University of Utah
Timothy D Smith, The Christ Hospital and Lindner Institute for Research and Education
R Jeffrey Snell, Rush University
Derek So, University of Ottawa
Michael A Solomon, University of Toronto
Bradley W Ternus, University of Wisconsin Colleges
Jeffrey J Teuteberg, Stanford UniversityFollow
Sean van Diepen, University of Alberta
Sammy Zakaria, Johns Hopkins University
David A Morrow, Brigham and Women's Hospital

Publication/Presentation Date



AIMS: The aims of the Critical Care Cardiology Trials Network (CCCTN) are to develop a registry to investigate the epidemiology of cardiac critical illness and to establish a multicenter research network to conduct randomized clinical trials (RCTs) in patients with cardiac critical illness.

METHODS AND RESULTS: The CCCTN was founded in 2017 with 16 centers and has grown to a research network of over 40 academic and clinical centers in the United States and Canada. Each center enters data for consecutive cardiac intensive care unit (CICU) admissions for at least two months of each calendar year. More than 20 000 unique CICU admissions are now included in the CCCTN Registry. To date, scientific observations from the CCCTN Registry include description of variations in care, the epidemiology and outcomes of all CICU patients, as well as subsets of patients with specific disease states, such as shock, heart failure, renal dysfunction, and respiratory failure. The CCCTN has also characterized utilization patterns, including use of mechanical circulatory support in response to changes in the heart transplantation allocation system, and the use and impact of multidisciplinary shock teams. Over years of multicenter collaboration, the CCCTN has established a robust research network to facilitate multicenter registry-based randomized trials in patients with cardiac critical illness.

CONCLUSIONS: The CCCTN is a large, prospective registry dedicated to describing processes-of-care and expanding clinical knowledge in cardiac critical illness. The CCCTN will serve as an investigational platform from which to conduct randomized controlled trials in this important patient population.




Medicine and Health Sciences




Cardiology Division, Department of Medicine

Document Type