Critical Care Cardiology Trials Network (CCCTN): a cohort profile.

Authors

• Thomas S Metkus, Johns Hopkins University
• Vivian M Baird-Zars, Brigham and Women's HospitalFollow
• Carlos E Alfonso, University of Miami
• Carlos L Alviar, New York UniversityFollow
• Christopher F Barnett, University of California, San FranciscoFollow
• Gregory W Barsness, Mayo ClinicFollow
• David D Berg, Brigham and Women's HospitalFollow
• Mia Bertic, University of Toronto Etobicoke
• Erin A Bohula, Brigham and Women's HospitalFollow
• James Burke MD, Lehigh Valley Health NetworkFollow
• Barry Burstein, University of Toronto
• Sunit-Preet Chaudhry, St. Vincent Heart CenterFollow
• Howard A Cooper, Westchester Medical Center and New York Medical College
• Lori B Daniels, University of California - San DiegoFollow
• Christopher B Fordyce, University of British ColumbiaFollow
• Shahab Ghafghazi, University of Louisville
• Michael Goldfarb, McGill University
• Jason N Katz, Duke University
• Ellen C Keeley, University of Florida
• Norma M Keller, New York University
• Benjamin Kenigsberg, MedStar Washington Hospital Center
• Michael C Kontos, Virginia Commonwealth University
• Younghoon Kwon, University of Washington
• Patrick R Lawler, University of Toronto
• Evan Leibner, Mount Sinai Hospital
• Shuangbo Liu, Max Rady College of Medicine
• Venu Menon, Cleveland Clinic Foundation
• P Elliott Miller, Yale University
• L Kristin Newby, Duke University
• Connor G O'Brien, University of California, San Francisco
• Alexander I Papolos, MedStar Washington Hospital Center
• Matthew J Pierce, Zucker School of Medicine at Hofstra/Northwell
• Rajnish Prasad, Wellstar Cardiovascular Medicine
• Barbara Pisani, Atrium Wake Forest Baptist
• Brian J Potter, Centre Hospitalier de l'Université de Montréal
• Robert O Roswell, Lenox Hospital, Northwell Health
• Shashank S Sinha, Inova Fairfax Medical Center
• Kevin S Shah, University of Utah
• Timothy D Smith, The Christ Hospital and Lindner Institute for Research and Education
• R Jeffrey Snell, Rush University
• Derek So, University of Ottawa
• Michael A Solomon, University of Toronto
• Bradley W Ternus, University of Wisconsin Colleges
• Jeffrey J Teuteberg, Stanford UniversityFollow
• Sean van Diepen, University of Alberta
• Sammy Zakaria, Johns Hopkins University
• David A Morrow, Brigham and Women's Hospital

Publication/Presentation Date

8-27-2022

Abstract

AIMS: The aims of the Critical Care Cardiology Trials Network (CCCTN) are to develop a registry to investigate the epidemiology of cardiac critical illness and to establish a multicenter research network to conduct randomized clinical trials (RCTs) in patients with cardiac critical illness.

METHODS AND RESULTS: The CCCTN was founded in 2017 with 16 centers and has grown to a research network of over 40 academic and clinical centers in the United States and Canada. Each center enters data for consecutive cardiac intensive care unit (CICU) admissions for at least two months of each calendar year. More than 20 000 unique CICU admissions are now included in the CCCTN Registry. To date, scientific observations from the CCCTN Registry include description of variations in care, the epidemiology and outcomes of all CICU patients, as well as subsets of patients with specific disease states, such as shock, heart failure, renal dysfunction, and respiratory failure. The CCCTN has also characterized utilization patterns, including use of mechanical circulatory support in response to changes in the heart transplantation allocation system, and the use and impact of multidisciplinary shock teams. Over years of multicenter collaboration, the CCCTN has established a robust research network to facilitate multicenter registry-based randomized trials in patients with cardiac critical illness.

CONCLUSIONS: The CCCTN is a large, prospective registry dedicated to describing processes-of-care and expanding clinical knowledge in cardiac critical illness. The CCCTN will serve as an investigational platform from which to conduct randomized controlled trials in this important patient population.

ISSN

2058-1742

Published In/Presented At

Metkus TS, Baird-Zars VM, Alfonso CE, Alviar CL, Barnett CF, Barsness GW, Berg DD, Bertic M, Bohula EA, Burke J, Burstein B, Chaudhry SP, Cooper HA, Daniels LB, Fordyce CB, Ghafghazi S, Goldfarb M, Katz JN, Keeley EC, Keller NM, Kenigsberg B, Kontos MC, Kwon Y, Lawler PR, Leibner E, Liu S, Menon V, Miller PE, Newby LK, O'Brien CG, Papolos AI, Pierce MJ, Prasad R, Pisani B, Potter BJ, Roswell RO, Sinha SS, Shah KS, Smith TD, Snell RJ, So D, Solomon MA, Ternus BW, Teuteberg JJ, van Diepen S, Zakaria S, Morrow DA. Critical Care Cardiology Trials Network (CCCTN): a cohort profile. Eur Heart J Qual Care Clin Outcomes. 2022 Aug 27:qcac055. doi: 10.1093/ehjqcco/qcac055. Epub ahead of print. PMID: 36029517.

Disciplines

Medicine and Health Sciences

PubMedID

36029517

Department(s)

Cardiology Division, Department of Medicine

Document Type

Article