Platelet C4d is associated with acute ischemic stroke and stroke severity.
BACKGROUND AND PURPOSE: Platelets bearing complement C4d were recently reported to be 99% specific for a diagnosis of systemic lupus erythematosus (SLE) and associated with neuropsychiatric lupus. We compared the prevalence of platelet C4d and investigated the clinical associations of platelet C4d in patients with acute ischemic stroke.
METHODS: We recruited 80 patients hospitalized for acute ischemic stroke. Stroke severity was measured by the National Institutes of Health Stroke Scale (NIH-SS). Infarct volume was determined by MRI. Platelet C4d was measured by flow cytometry.
RESULTS: Mean age was 57.9 years (range: 24.6 to 86.8 years), 58% were male, and 91% were white. Eight patients (10%) with acute ischemic stroke were platelet C4d-positive, which was significantly higher in prevalence compared to healthy controls (0%, P
CONCLUSIONS: Platelet C4d is associated with severe acute ischemic stroke. Platelet C4d may be a biomarker as well as pathogenic clue that links cerebrovascular inflammation and thrombosis.
Published In/Presented At
Mehta, N., Uchino, K., Fakhran, S., Sattar, M. A., Branstetter, B. F., 4th, Au, K., Navratil, J. S., Paul, B., Lee, M., Gallagher, K. M., Manzi, S., Ahearn, J. M., & Kao, A. H. (2008). Platelet C4d is associated with acute ischemic stroke and stroke severity. Stroke, 39(12), 3236–3241. https://doi.org/10.1161/STROKEAHA.108.514687
Medicine and Health Sciences
Department of Medicine, Cardiology Division