Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.

Authors

• J Blaze
• A Navickas
• H L Phillips
• S Heissel
• A Plaza-Jennings
• S Miglani
• H Asgharian
• M Foo
• C D Katanski
• C P Watkins
• Z T Pennington
• B Javidfar
• S Espeso-Gil
• B Rostandy
• H Alwaseem
• C G Hahn
• H Molina
• D J Cai
• T Pan
• W D Yao
• H Goodarzi
• F Haghighi
• S Akbarian

Publication/Presentation Date

8-13-2021

Abstract

Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation and transgene-derived overexpression of Nsun2 in the mouse prefrontal cortex (PFC). Neuronal Nsun2-deficiency was associated with a decrease in tRNA m

Volume

12

Issue

1

First Page

4913

Last Page

4913

ISSN

2041-1723

Published In/Presented At

Blaze, J., Navickas, A., Phillips, H. L., Heissel, S., Plaza-Jennings, A., Miglani, S., Asgharian, H., Foo, M., Katanski, C. D., Watkins, C. P., Pennington, Z. T., Javidfar, B., Espeso-Gil, S., Rostandy, B., Alwaseem, H., Hahn, C. G., Molina, H., Cai, D. J., Pan, T., Yao, W. D., … Akbarian, S. (2021). Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior. Nature communications, 12(1), 4913. https://doi.org/10.1038/s41467-021-24969-x

Disciplines

Medicine and Health Sciences

PubMedID

34389722

Department(s)

Medical Education

Document Type

Article