An Observational Study of the Effect of Concomitant Levetiracetam on Apixaban Concentrations in a Hospital Cohort.

Authors

• Chazmyn Riley
• Kevin Lam
• Cristina Micale
• Lynda Thomson
• Douglas F Stickle
• Walter K Kraft

Publication/Presentation Date

9-1-2026

Abstract

Despite the lack of evidence of a mechanism-based drug interaction, some professional organizations have advised caution coadministering apixaban and levetiracetam. Eligible patients taking apixaban with or without levetiracetam for any indication for at least 72 h were screened from the electronic medical records. Plasma samples from 77 patients were retrieved from salvaged clinical blood collections. Apixaban minimum and maximum concentrations (C

Volume

19

Issue

9

First Page

70719

Last Page

70719

ISSN

1752-8062

Published In/Presented At

Riley, C., Lam, K., Micale, C., Thomson, L., Stickle, D. F., & Kraft, W. K. (2026). An Observational Study of the Effect of Concomitant Levetiracetam on Apixaban Concentrations in a Hospital Cohort. Clinical and translational science, 19(9), e70719. https://doi.org/10.1111/cts.70719

PubMedID

42681674

Department(s)

Medical Education

Document Type

Article