The Effect of Low-Dose Epsilon-Aminocaproic Acid on Patients Following Coronary Artery Bypass Surgery.
The effect of low-dose epsilon-aminocaproic acid (EACA) on the postoperative course of 46 patients was studied. Patients undergoing coronary artery bypass grafting were randomly selected in two groups. Group 1 (20 patients) received 5 g EACA upon initiation of cardiopulmonary bypass (CPB). Group 2 (26 patients) received no antifibrinolytic drugs prior to CPB. Neither group received antifibrinolytic drugs after CPB. There was no significant difference between the two groups' blood usage on CPB: 0.65 units in Group 1 and 0.60 units in Group 2. After CPB, blood usage significantly differed: 2.2 +/- 1.7 (SD) units in Group 1 and 3.9 +/- 3.0 units in Group 2 (p = 0.033). Significant difference was also demonstrated in postoperative blood loss in the first 24 hours: 1610 +/- 531 ml in Group 1 versus 2025 +/- 804 ml in Group 2 (p = 0.043). Pre-CPB administration of low-dose EACA significantly decreases blood loss and blood usage in the postoperative period.
Published In/Presented At
Montesano, R. M., Gustafson, P. A., Palanzo, D. A., Manley, N. J., & Sadr, F. S. (1996). The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery bypass surgery. Perfusion, 11(1), 53-56.
Medical Sciences | Medicine and Health Sciences | Surgery
Department of Medicine