Red cell Distribution Width and Risk of Cardiovascular Mortality: Insights from National Health and Nutrition Examination Survey (NHANES)-III.
INTRODUCTION: Red cell distribution width (RDW) has been linked to cardiovascular disease. We sought to determine whether addition of RDW improved the Framingham risk score (FRS) model to predict cardiovascular mortality in a healthy US cohort.
METHODS: We performed a post-hoc analysis of the National Health and Nutritional Examination Survey-III (1988-94) cohort, including non-anemic subjects aged 30-79years. Primary endpoint was death from coronary heart disease (CHD). We divided the cohort into three risk categories:20%. RDW>14.5 was considered high. Kaplan-Meier survival curves and Cox proportional hazards models were created. Discrimination, calibration and reclassification were used to assess the value of addition of RDW to the FRS model.
RESULTS: We included 7005 subjects with a mean follow up of 14.1years. Overall, there were 233 (3.3%) CHD deaths; 27 (8.2%) in subjects with RDW>14.5 compared to 206 (3.1%) in subjects with RDW≤14.5 (p
CONCLUSIONS: Our study demonstrates that RDW is a promising biomarker which improves prediction of cardiovascular mortality over and above traditional cardiovascular risk factors.
Published In/Presented At
Shah, N., Pahuja, M., Pant, S., Handa, A., Agarwal, V., Patel, N., & Dusaj, R. (2017). Red cell distribution width and risk of cardiovascular mortality: Insights from National Health and Nutrition Examination Survey (NHANES)-III. International Journal Of Cardiology, 232105-110. doi:10.1016/j.ijcard.2017.01.045
Cardiology | Medical Sciences | Medicine and Health Sciences
Department of Medicine, Cardiology Division