Title

Two hundred and eleven cases of Candida osteomyelitis: 17 case reports and a review of the literature.

Publication/Presentation Date

5-1-2012

Abstract

Candida osteomyelitis is a rare infection. We present 17 cases of Candida osteomyelitis from our institution and review 194 patients from the literature. The median age of patients was 57 ± 22 years (range, 18-90 years) with 68% male. Comorbidities associated with this infection include prior surgery (62%), broad-spectrum antibiotics (40%), central venous catheter insertion (19%), and immunosuppression (17%). The most common infecting species were Candida albicans (69%), Candida tropicalis (15%), and Candida glabrata (8%). Most initial antifungal regimens included amphotericin B (59%); however, fluconazole is increasingly being utilized for treatment of this infection (26%). Echinocandins were used infrequently (4%). Median length of treatment was 3 ± 4.5 months (mean, 4.2 months; range, 18 days to 36 months). The overall success rate of therapy was 91%, with 75% of patients cured by 6 months. The crude mortality rate was 12% with an attributable mortality rate of 6%.

Volume

73

Issue

1

First Page

89

Last Page

93

ISSN

1879-0070

Disciplines

Medical Sciences | Medicine and Health Sciences

PubMedID

22578942

Department(s)

Department of Medicine, Department of Medicine Faculty

Document Type

Article

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