Title

Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response.

Publication/Presentation Date

11-1-2005

Abstract

HYPOTHESIS: Analysis of multiple clinical and pathological factors in patients undergoing therapeutic hyperthermic isolated limb perfusion for extremity melanoma can identify variables with prognostic significance.

DESIGN: Retrospective review of a prospectively collected limb perfusion database with a median follow-up interval of 32.2 months.

SETTING: Single-institution tertiary care surgical oncology unit.

PATIENTS: We report a series of 59 consecutive therapeutic hyperthermic isolated limb perfusion treatments (14 upper extremity and 45 lower extremity) in 54 patients with melanoma from January 1, 1995, through December 31, 2002, using a standard melphalan dosing protocol. At the time of perfusion, 31 cases had fewer than 10 lesions, with none greater than 3 cm in diameter. The remaining 28 cases had 10 or more lesions or at least 1 lesion greater than 3 cm in diameter.

MAIN OUTCOME MEASURES: Response, recurrence, and survival were assessed in relation to multiple demographic, clinical, and technical variables using chi2, log-rank, and Kaplan-Meier survival analyses.

RESULTS: The 3-year survival for the entire cohort was 54%. Thirty-three (56%) of the 59 perfusion treatments resulted in a persistent complete response of at least 6 months' duration. Statistical analysis showed that patients with no evidence of regional nodal involvement had a significantly lower incidence of distant recurrence (P = .02). Those patients achieving a complete response to therapy had a survival advantage (P = .03).

CONCLUSION: In patients undergoing therapeutic hyperthermic isolated limb perfusion for in-transit melanoma, the ability to achieve a complete response following treatment, independent of regional nodal status, was the strongest predictor of long-term survival.

Volume

140

Issue

11

First Page

1115

Last Page

1120

ISSN

0004-0010

Disciplines

Oncology | Surgery

PubMedID

16301451

Department(s)

Department of Surgery, Department of Surgery Faculty, Hematology-Medical Oncology Division

Document Type

Article

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