Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: a review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual.
Publication/Presentation Date
2-1-2004
Abstract
Exogenous agents implicated in or suspected of precipitating subacute cutaneous lupus erythematosus (SCLE) and lupus erythematosus (LE) are reviewed. An illustrative case of environmentally induced SCLE is presented. A previously healthy 30-year male homozygous for the tumor necrosis factor-alpha (TNF-alpha) 308. A promoter allele developed SCLE after spending several hours removing fertilizer- and pesticide-containing hay from an agricultural barn in the springtime. The cutaneous eruption soon resolved, only to reappear 3 weeks later on the day the patient re-entered the barn. An environmental agent present in the barn, coupled with springtime ultraviolet light, likely triggered the disease in this immunogenetically susceptible individual.
Volume
43
Issue
2
First Page
87
Last Page
94
ISSN
0011-9059
Published In/Presented At
Shapiro, M., Sosis, A. C., Junkins-Hopkins, J. M., & Werth, V. P. (2004). Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: a review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual. International Journal Of Dermatology, 43(2), 87–94.
Disciplines
Dermatology
PubMedID
15125497
Department(s)
Department of Medicine, Department of Medicine Faculty
Document Type
Article