Oxidative stress in etiopathogenesis of inflammatory bowel diseases
Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown origin. The etiology of IBD is multifactorial and involves interaction between genetic, environmental and immunological factors with oxidative stress being an inherent part of any one of them. Therefore, the redox equilibrium is crucial to maintain cell homeostasis in the gastrointestinal (GI) tract, which is constantly exposed to large numbers of commensal and pathological bacteria. Distortion of this homeostasis and increase in oxidative stress leads to the propagation of inflammation, mucosal injury in the GI tract and is associated with the development and exacerbation of IBD.
Published In/Presented At
Kloska, M., Mańkowska-Wierzbicka, D., Człapka-Matyasik, M., Dobrowolska, A., & Grzymisławski, M. (2020). Stres oksydacyjny w etiopatogenezie nieswoistych chorób zapalnych jelit [Oxidative stress in etiopathogenesis of inflammatory bowel diseases]. Postepy biochemii, 66(2), 143–150. https://doi.org/10.18388/pb.2020_324
Medicine and Health Sciences
Department of Medicine