Title

Ménétrier disease in an acquired immunodeficiency syndrome patient.

Publication/Presentation Date

1-1-2010

Abstract

Ménétrier disease is a rare disorder of unknown etiology. An overexpression of TGF-alpha has been proposed to play a role in the pathophysiology. HIV-1 tat gene product has been shown to stimulate TGF-alpha production leading to a positive feedback autocrine loop. The case of a 41-year-old male with AIDS who presented with weight loss, abdominal pain, ascites, edema, nausea, vomiting, and diarrhea is discussed. A computed tomography (CT) scan of the abdomen showed avid enhancement of the stomach mucosa. Magnetic resonance angiography revealed gastric and small bowel distention with diffuse wall thickening. Biopsies of the stomach showed marked foveolar hyperplasia with active inflammation and gland changes consistent with Ménétrier disease.

Volume

103

Issue

1

First Page

93

Last Page

95

ISSN

1541-8243

Disciplines

Medicine and Health Sciences

PubMedID

19996862

Department(s)

Department of Medicine

Document Type

Article

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