An unusual subacute progressive motor neuronopathy with myasthenia-like features.
The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of conjugate gaze paresis and the absence of many of the typical clinical and electromyographic (EMG) findings seen in this condition. The pathological findings were consistent with either a motor neuronopathy or an unusual variant of ALS. We review the clinical and pathological features of this unusual case in this report.
Published In/Presented At
Noseworthy, J. H., Rae-Grant, A. D., & Brown, W. F. (1988). An unusual subacute progressive motor neuronopathy with myasthenia-like features. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 15(3), 304–309. https://doi.org/10.1017/s0317167100027797
Medicine and Health Sciences
Department of Medicine