Dual-opioid therapy: changing the paradigm. Introduction.
INTRODUCTION: Morphine sulfate and oxycodone hydrochloride are commonly used for pain management because of their pharmacologic profile, pharmacokinetics, and analgesic potency. However, opioids are associated with a significant adverse event (AE) burden that limits their use in both the acute and the chronic pain settings.
SUMMARY: Co-administration of opioids demonstrated synergistic analgesia and reduced side effects. Thus, dual-opioid therapy has the potential to enhance the positive analgesic benefits of opioids, while limiting the burden of opioid-related AEs. This symposium proceedings was based on presentations at the 13th World Congress on Pain in August 2010.
CONCLUSIONS: This program will review the rationale for dual-opioid therapy based on preclinical findings and data from clinical studies showing the efficacy and tolerability profile of a dual-opioid formulation when used to treat acute postoperative pain.
13 Suppl 1
Published In/Presented At
Nicholson B. D. (2012). Dual-opioid therapy: changing the paradigm. Introduction. Pain medicine (Malden, Mass.), 13 Suppl 1, S1–S3. https://doi.org/10.1111/j.1526-4637.2012.01342.x
Medicine and Health Sciences
Department of Medicine