Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies.

Authors

Lucas Nogueira
Andrew T Tracey
Ricardo Alvim
Peter A Reisz MD, Lehigh Valley Health NetworkFollow
Avigdor Scherz
Jonathan A Coleman
Kwanghee Kim

Publication/Presentation Date

11-19-2020

Abstract

With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.

Volume

25

Issue

22

ISSN

1420-3049

Published In/Presented At

Nogueira, L., Tracey, A. T., Alvim, R., Reisz, P., Scherz, A., Coleman, J. A., & Kim, K. (2020). Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies. Molecules (Basel, Switzerland), 25(22), 5417. https://doi.org/10.3390/molecules25225417

Disciplines

Medicine and Health Sciences

PubMedID

33228126

Department(s)

Department of Medicine

Document Type

Article