Why Do Lifestyle Recommendations Fail in Most Patients with Nonalcoholic Fatty Liver Disease?
Nonalcoholic fatty liver disease has been recognized as a major health burden. The efficacy and safety profile of pharmacotherapy in the treatment of nonalcoholic fatty liver disease remains uncertain; therefore, lifestyle modification is the first line of treatment. Based on available data, patients should optimally achieve at least a 5% to 10% weight reduction for histologic improvement. There is no clear consensus on the optimal diet or exercise regimen. Sustainability of any intervention is key to success; however, compliance has been a major issue in clinical trials. This finding underscores the importance of multidisciplinary strategies to achieve targeted weigh loss.
Published In/Presented At
Hernandez Roman, J., & Patel, S. (2020). Why Do Lifestyle Recommendations Fail in Most Patients with Nonalcoholic Fatty Liver Disease?. Gastroenterology clinics of North America, 49(1), 95–104. https://doi.org/10.1016/j.gtc.2019.10.001
Medicine and Health Sciences
Department of Medicine