Pulmonary sarcoidosis and latent tuberculosis in a patient with psoriasis treated with adalimumab.
Publication/Presentation Date
1-15-2015
Abstract
Tumor necrosis factor (TNF) inhibitors are powerful biologic medications that have been used successfully in the treatment of a variety of inflammatory conditions, including psoriasis. Although TNF inhibitors are generally well tolerated, their use increases the risk of infections such as tuberculosis (TB), and paradoxically, they have been associated with development of sarcoidosis. We report the case of a 54-year old man with plaque psoriasis who developed a positive TB test and pulmonary sarcoidosis after 12 months of adalimumab treatment. After stopping adalimumab, his psoriasis worsened and he was started on ustekinumab and narrowband UVB, with improvement in symptoms. We provide a review of the literature and discuss treatment challenges.
Volume
21
Issue
1
ISSN
1087-2108
Published In/Presented At
Korta, D. Z., Ochieng, P., Fishman, D., & Katz, S. E. (2015). Pulmonary sarcoidosis and latent tuberculosis in a patient with psoriasis treated with adalimumab. Dermatology online journal, 21(1), 13030/qt95j8f3t4.
Disciplines
Medicine and Health Sciences
PubMedID
25612132
Department(s)
Department of Medicine
Document Type
Article