The electroencephalogram in Alzheimer-type dementia. A sequential study correlating the electroencephalogram with psychometric and quantitative pathologic data.
Publication/Presentation Date
1-1-1987
Abstract
As part of a longitudinal cohort study of dementia, 139 patients with Alzheimer's disease (dementia of the Alzheimer type, senile dementia of the Alzheimer type, and mixed type [ischemic score, 4 to 7]) and 148 age-matched control subjects were evaluated for electroencephalographic (EEG) abnormalities and their evolution. Electroencephalograms were significantly different in the two groups; EEGs worsened overall in the two groups during a period of one to four years, but most subjects showed no alteration in their EEGs. Some patients showed improvement in their EEG findings during the follow-up period. A strong correlation between EEG grade and psychometric scores was consistently found over sequential studies. In a subgroup of patients on whom autopsies were performed, morphometric neuron loss correlated significantly with EEG severity.
Volume
44
Issue
1
First Page
50
Last Page
54
ISSN
0003-9942
Published In/Presented At
Rae-Grant, A., Blume, W., Lau, C., Hachinski, V. C., Fisman, M., & Merskey, H. (1987). The electroencephalogram in Alzheimer-type dementia. A sequential study correlating the electroencephalogram with psychometric and quantitative pathologic data. Archives of neurology, 44(1), 50–54. https://doi.org/10.1001/archneur.1987.00520130042015
Disciplines
Medicine and Health Sciences
PubMedID
3800722
Department(s)
Department of Medicine
Document Type
Article