Direct detection of cellular immune responses to cancer vaccines.
The evaluation of cancer immunotherapy is predicated on the hypothesis that markers of tumor antigen-specific T-cell immunity will cone-late with clinical efficacy. Establishing which candidate vaccines should enter large-scale clinical trials will necessitate optimal application of immunologic monitoring assays. Evidence suggests that available techniques are adequate for the direct detection of clinically significant antigen-specific T-cell responses from tissue specimens. To achieve this goal, it is important to have an understanding of individual methods and their limitations, to include appropriate control antigens in the monitoring strategy, and to incorporate statistical considerations into the design and analysis of such studies.
Published In/Presented At
Mosca, P. J., Hobeika, A. C., Clay, T. M., Morse, M. A., & Lyerly, H. K. (2001). Direct detection of cellular immune responses to cancer vaccines. Surgery, 129(3), 248–254. https://doi.org/10.1067/msy.2001.108609
Medicine and Health Sciences
Department of Medicine