Treatment of intractable rheumatoid arthritis with total lymphoid irradiation (TLI): immunological and clinical changes.
Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation in a feasibility study. The mantle and the inverted Y fields were treated successively to a cumulative dose of 2000 rads. Nine of eleven patients showed at least a 35% improvement in three of four clinical parameters by six months and continued to maintain at least this level of improvement at their last observation points (13-28 months after TLI). There was a marked decrease in the percentage of total T cells and Leu-3 cells (helper), but an increase in the percentage of Leu-2 cells (suppressor/cytotoxic), resulting in a dramatic increase in the Leu-2/Leu-3 ratio. There was also a decrease in response to PHA, Con A and MLR.
Published In/Presented At
Strober, S., Field, E. M., Kotzin, B. L., Hoppe, R. T., Engleman, E. C., Tanay, A. S., & Kaplan, H. S. (1983). Treatment of intractable rheumatoid arthritis with total lymphoid irradiation (TLI): immunological and clinical changes. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1(1), 43–52. https://doi.org/10.1016/s0167-8140(83)80006-1
Medicine and Health Sciences
Department of Medicine