Fitness of cell-mediated immunity independent of repertoire diversity.
Fitness of cell-mediated immunity is thought to depend on TCR diversity; however, this concept has not been tested formally. We tested the concept using JH(-/-) mice that lack B cells and have TCR Vbeta diversity99% and defective lymphoid organogenesis, JH(-/-) mice rejected H-Y-incompatible skin grafts as rapidly as wild-type mice. JH(-/-) mice exhibited T cell priming by peptide and delayed-type hypersensitivity, although these responses were less than normal owing either to TCR repertoire contraction or defective lymphoid organogenesis. QM mice with TCR diversity contracted >90%, and normal lymphoid organs rejected H-Y incompatible skin grafts as rapidly as wild type mice and exhibited normal T cell priming and normal delayed-type hypersensitivity reactions. QM mice also resisted Pneumocystis murina like wild-type mice. Thus, cell-mediated immunity can function normally despite contractions of TCR diversity >90% and possibly >99%.
Published In/Presented At
AbuAttieh, M., Rebrovich, M., Wettstein, P. J., Vuk-Pavlovic, Z., Limper, A. H., Platt, J. L., & Cascalho, M. (2007). Fitness of cell-mediated immunity independent of repertoire diversity. Journal of immunology (Baltimore, Md. : 1950), 178(5), 2950–2960. https://doi.org/10.4049/jimmunol.178.5.2950
Medicine and Health Sciences
Department of Medicine