Reversibility of Murine Motor Deficits Following Hemi-Craniectomy and Cranioplasty.
BACKGROUND: Hemi-craniectomy is a common surgical procedure which allows the brain to swell and herniate and is often utilized to treat traumatic brain injury. When left untreated the scalp skin typically sinks on the side of the craniectomy creating a phenotype termed "sinking skin flap syndrome." In addition, these same patients often develop long-term neurocognitive deficits termed "syndrome of the trephined" as a result of their craniectomy which reverse when the cranial skull is replaced. The authors hypothesize that a mouse animal model can be developed demonstrating long-term neurologic deficits attributed to hemi-craniectomy skull defects similar to humans with syndrome of the trephined.
METHODS: Thirty C57 mice were randomized among 3 groups: Group 1 = control group (sham surgery), Group 2 = hemi-craniectomy only, and Group 3 = hemi-craniectomy with immediate cranioplasty. Motor deficits were studied using a beam walk test. Statistical comparison of differences among the 3 groups was performed.
RESULTS: Beam walk test results demonstrated the craniectomy group had a statistically higher contralateral footfault slip/step ratio when compared with the control group (P
CONCLUSION: Motor deficits that are attributed to hemi-craniectomy bone defects alone are demonstrated in a mouse animal model. These motor deficits resemble some symptoms associated with human syndrome of the trephined.
Published In/Presented At
Andrews, B. T., Lydick, A., Barbay, S., Reisz, P., & Nudo, R. J. (2016). Reversibility of Murine Motor Deficits Following Hemi-Craniectomy and Cranioplasty. The Journal of craniofacial surgery, 27(7), 1875–1878. https://doi.org/10.1097/SCS.0000000000002897
Medicine and Health Sciences
Department of Medicine