Necrosis of the skin developed soon after the initiation of coumarin therapy in an elderly woman. Inadvertent rechallenge resulted in similar lesions. Coumarin necrosis is a poorly understood phenomenon unlikely to respond to therapy. Fortunately, its incidence is quite rare, considering the widespread use of this anticoagulant.
Published In/Presented At
Schleicher, S. M., & Fricker, M. P. (1980). Coumarin necrosis. Archives of dermatology, 116(4), 444–445.
Medicine and Health Sciences
Department of Medicine