Effects of bicarbonate-containing versus lactate-containing peritoneal dialysis solutions on superoxide production by human neutrophils.
Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate-containing (pH 7.4) or lactate-containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Bicarbonate-containing peritoneal dialysis solution was found to be superior to the lactate-containing one in facilitating the production of superoxide anion by human neutrophils.
Published In/Presented At
Manahan, F. J., Ing, B. L., Chan, J. C., Gupta, D. K., Zhou, F. Q., Pal, I., & Rahman, M. A. (1989). Effects of bicarbonate-containing versus lactate-containing peritoneal dialysis solutions on superoxide production by human neutrophils. Artificial organs, 13(6), 495–497. https://doi.org/10.1111/j.1525-1594.1989.tb01568.x
Medicine and Health Sciences
Department of Medicine