Cryoglobulin crystal arthropathy in a patient with multiple myeloma.
Joint involvement is unusual in patients with monoclonal gammopathies. It has been characteristically described as a rheumatoid-like seronegative polyarticular erosive arthropathy, which also has been related to crystal deposition of cryoglobulins in the synovium and several other tissues. This report describes the case of a 57-year-old African American woman with a seronegative polyarthritis associated with deposition of nonbirefringent or weakly positive birefringent rhomboid-shaped crystals in the synovial fluid. The patient, who was subsequently diagnosed with multiple myeloma, showed good clinical response to oral and intra-articular corticosteroids. Type II cryoglobulins were identified in the serum as well as in the synovial fluid. It is important to consider this association as part of the differential diagnosis of a patient with multiple myeloma and arthritis.
Published In/Presented At
Rodriguez-Paez, A. C., Seetharaman, M., & Brent, L. H. (2009). Cryoglobulin crystal arthropathy in a patient with multiple myeloma. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 15(5), 238–240. https://doi.org/10.1097/RHU.0b013e3181a567b5
Medicine and Health Sciences
Department of Medicine