Embryonic synergism may reduce pregnancy loss: a multivariate regression analysis.

Publication/Presentation Date

3-1-2007

Abstract

OBJECTIVE: To evaluate clinical and assisted reproductive technology (ART) cycle variables related to spontaneous embryo reduction.

DESIGN: Observational retrospective cohort study.

SETTING: Private ART center.

PATIENT(S): A total of 3,467 patients achieving a first-trimester pregnancy after IVF.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Rate of any spontaneous embryo reduction and rate of spontaneous single embryo reduction.

RESULT(S): Adjusting for all analyzed variables, only initial gestational sac count, age, and body mass index were associated with the spontaneous embryo reduction rate. Twins had a lower chance of having a spontaneous embryo reduction than singletons (odds ratio 0.6, 95% confidence interval 0.50-0.79). When only spontaneous single embryo reduction was assessed, women with two or three initial gestational sacs were less prone to have a spontaneous single embryo reduction than women with one initial gestational sac.

CONCLUSION(S): When spontaneous embryo reduction and spontaneous single embryo reduction were evaluated independently of other clinical and ART cycle variables, they were less frequent in twin pregnancies than in singleton pregnancies. This suggests a role for embryonic synergism in sustaining implantation.

Volume

87

Issue

3

First Page

509

Last Page

514

ISSN

1556-5653

Disciplines

Medicine and Health Sciences

PubMedID

17140577

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

Link to Full Text

Share

COinS