Response of ovine uterine blood flow to angiotensin II: effect on the fetus.
The effect of intravenous infusion of angiotensin II (2 to 200 ng/kg/min) on uterine blood flow and cardiovascular performance was studied in the normotensive, unanesthetized pregnant ewe. With low rates of infusion (2 to 4 ng/kg/min), only a transient increase in uterine blood flow, lasting 1 to 3 minutes, was observed. Higher rates (110 to 200 ng/kg/min) of infusion caused a decrease in uterine blood flow; this decrease was significantly correlated to the dose. Angiotensin II also caused a significant decrease in the maternal heart rate and an increase in mean maternal arterial blood pressure as the rate of infusion was increased. A high rate of infusion resulted in decreased fetal heart rate and PaO2, probably due to a marked reduction in uteroplacental blood flow.
Published In/Presented At
Bruce SL, Morishima HO, Petrie RH, Sakuma K, Daniel SS, Yeh SY. Response of ovine uterine blood flow to angiotensin II: effect on the fetus. Am J Obstet Gynecol. 1981 Nov 1;141(5):495-8. doi: 10.1016/s0002-9378(15)33267-1. PMID: 7294075.
Medicine and Health Sciences
Department of Obstetrics and Gynecology