Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: case report and review of the literature.
Publication/Presentation Date
4-1-2005
Abstract
We report a case of anaplastic large cell lymphoma (ALCL) with central nervous system relapse in an 11-year-old boy. The relapse was suspected on morphologic examination of the cytospin preparations of the cerebrospinal fluid (CSF) with a WBC of 10 cells/microl. CSF relapse was confirmed using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and reverse transcriptase-polymerase chain reaction (RT-PCR) for abnormal ALK expression or gene structure. The patient developed large intracranial metastases, despite systemic, and intrathecal chemotherapy. This case demonstrates the feasibility of detecting ALCL in paucicellular CSF specimens and suggests that even low CSF involvement can herald massive parenchymal disease.
Volume
44
Issue
4
First Page
400
Last Page
406
ISSN
1545-5009
Published In/Presented At
Armstrong, G., Szallasi, A., Biegel, J. A., Shurtleff, S., Bilaniuk, L. T., Womer, R. B., & Choi, J. K. (2005). Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: case report and review of the literature. Pediatric blood & cancer, 44(4), 400–406. https://doi.org/10.1002/pbc.20250
Disciplines
Medicine and Health Sciences
PubMedID
15515044
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article