The Short-Term Effect of Low-Dose Radiation on Intracranial Germinoma. A Pathologic Study.
A correlative pathologic and imaging (computed tomography and magnetic resonance imaging) study is reported of a pineal germinoma in a 35-year-old man who died unexpectedly of massive pulmonary embolism on the 8th day during the course of radiation therapy after receiving a total dose of only 1600 cGy. A histologic study of the entire lesion in serial sections revealed no viable tumor cells. The tumor bed was composed of stromal elements with a variable degree of proliferation. The lymphocytic component of the tumor was unaffected by the radiation. This case provided a rare opportunity to show total eradication of tumor cells in a germinoma after a small dose of radiation and supports the notion, based on imaging observations, that histologically proven intracranial pure germinomas may be treated successfully with a much smaller dose of radiation than previously thought.
Published In/Presented At
Aydin, F., Ghatak, N. R., Radie-Keane, K., Kinard, J., & Land, S. D. (1992). The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. Cancer, 69(9), 2322-2326.
Medical Pathology | Pathology
Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty