Title

The Gene For The APC-Binding Protein Beta-Catenin (CTNNB1) Maps To Chromosome 3p22, A Region Frequently Altered In Human Malignancies.

Publication/Presentation Date

1-1-1995

Abstract

beta-Catenin is one of the E-cadherin associated proteins involved in the process of cellular adhesion. It has recently been shown to interact with the APC protein whose gene is known to be mutated in the germline of familial adenomatous polyposis patients. This interaction implies that beta-catenin is a potential regulator of the APC gene. The localization of the human beta-catenin gene (CTNNB1) to chromosome 3p22, by fluorescent in situ hybridization (FISH), has linked the gene to a region that is frequently altered in several human malignancies. The location of the gene and the protein interactions suggest the importance of beta-catenin in the etiology of various human cancers.

Volume

71

Issue

4

First Page

343

Last Page

344

ISSN

0301-0171

Disciplines

Medical Pathology | Pathology

PubMedID

8521721

Department(s)

Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty

Document Type

Article

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