Potassium changes associated with blood transfusion in pediatric patients.
Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of "fresh" pRBC units with routine pediatric transfusion.
Published In/Presented At
Olson, J., Talekar, M., Sachdev, M., Castellani, W., De la Cruz, N., Davis, J., Liao, J., & George, M. (2013). Potassium changes associated with blood transfusion in pediatric patients. American journal of clinical pathology, 139(6), 800–805. https://doi.org/10.1309/AJCP2MP8OIIXNKXF
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine