Cranial angiomatoid fibrous histiocytoma: A case report and review of literature.
BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare low-grade soft-tissue tumor that typically arises from the deep dermal and subcutaneous tissue of the extremities in children and young adults. Intracranial AFH is exceedingly rare, and only four cases of primary AFH tumors have been reported to date.
CASE DESCRIPTION: A 43-year-old male presented to our hospital with headaches, vision changes, and a known brain tumor suspected to be an atypical meningioma. After undergoing craniotomy for resection of the mass, the immunomorphologic features of the resected tumor showed typical features of AFH with ESWR1 (exon7) - ATF1 (exon 5) fusion.
CONCLUSION: AFH is a difficult tumor to diagnose with imaging and histologic studies. Thus, further knowledge is necessary - particularly of intracranial cases - to aid clinicians in its diagnosis and management.
Published In/Presented At
Sion, A. E., Tahir, R. A., Mukherjee, A., & Rock, J. P. (2020). Cranial angiomatoid fibrous histiocytoma: A case report and review of literature. Surgical neurology international, 11, 295. https://doi.org/10.25259/SNI_282_2020
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine