Retrospective, Observational Comparison of Eptifibatide vs Abciximab in Patients Undergoing Percutaneous Coronary Intervention
Purpose: To provide outcome data to health care practitioners involved in the care of patients undergoing percutaneous coronary intervention (PCI). Adjunctive treatment with eptifibatide can be used in a wide range of patients requiring glycoprotein IIb/IIIa inhibitors to attenuate platelet response secondary to coronary artery interventions requiring a stent. The use of eptifibatide will provide comparable revascularization protection and may be safer than using abciximab.
Methods: Preselected outcome measures were collected for consecutive patients receiving a glycoprotein IIb/IIIa inhibitor and the deployment of at least one coronary arterial stent for a 2-year period. The results were reported on a quarterly basis to the institution's cardiac interventionalists.
Results: No clinical or statistical differences in the event rate of a revascularization procedure for a “same target vessel” lesion at either the 6-month or 12-month evaluation periods were identified. The revascularization rate for “any vessel” interventions favored the use of abciximab at 6 months, but this advantage deteriorated at 12 months. Finally patients receiving eptifibatide were less likely to experience any bleeding event.
Conclusions: These outcome data can facilitate the use of eptifibatide in a wide range of patients undergoing PCI. An expectation of comparable clinical outcomes is merited. Based on these observations, the use of eptifibatide can at least provide a reduction in cost per procedural case.
Published In/Presented At
Ottinger, J. (2004 July). Retrospective, Observational Comparison of Eptifibatide vs Abciximab in Patients Undergoing Percutaneous Coronary Intervention. Hospital Pharmacy. 39(7), 661-665. doi.org/10.1177/001857870403900708.
Pharmacy and Pharmaceutical Sciences
Department of Pharmacy, Department of Pharmacy Faculty