Title

Retrospective, Observational Comparison of Eptifibatide vs Abciximab in Patients Undergoing Percutaneous Coronary Intervention

Publication/Presentation Date

7-2004

Abstract

Purpose: To provide outcome data to health care practitioners involved in the care of patients undergoing percutaneous coronary intervention (PCI). Adjunctive treatment with eptifibatide can be used in a wide range of patients requiring glycoprotein IIb/IIIa inhibitors to attenuate platelet response secondary to coronary artery interventions requiring a stent. The use of eptifibatide will provide comparable revascularization protection and may be safer than using abciximab.

Methods: Preselected outcome measures were collected for consecutive patients receiving a glycoprotein IIb/IIIa inhibitor and the deployment of at least one coronary arterial stent for a 2-year period. The results were reported on a quarterly basis to the institution's cardiac interventionalists.

Results: No clinical or statistical differences in the event rate of a revascularization procedure for a “same target vessel” lesion at either the 6-month or 12-month evaluation periods were identified. The revascularization rate for “any vessel” interventions favored the use of abciximab at 6 months, but this advantage deteriorated at 12 months. Finally patients receiving eptifibatide were less likely to experience any bleeding event.

Conclusions: These outcome data can facilitate the use of eptifibatide in a wide range of patients undergoing PCI. An expectation of comparable clinical outcomes is merited. Based on these observations, the use of eptifibatide can at least provide a reduction in cost per procedural case.

Volume

39

Issue

7

First Page

661

Last Page

665

Disciplines

Pharmacy and Pharmaceutical Sciences

Department(s)

Department of Pharmacy, Department of Pharmacy Faculty

Document Type

Article

This document is currently not available here.

Share

COinS