Low-dose rate prostate brachytherapy is well tolerated in patients with a history of inflammatory bowel disease.
PURPOSE: We report on the follow-up of 24 patients with a prior history of inflammatory bowel disease (IBD) treated with brachytherapy for early-stage prostate cancer.
METHODS AND MATERIALS: Twenty-four patients with a history of inflammatory bowel disease (17 with ulcerative colitis (UC), 7 with Crohn's disease [CD]) underwent prostate brachytherapy between 1992 and 2004. Fifteen patients were treated with I-125 implantation and 6 patients were treated with Pd-103 alone or in combination with 45 Gy external beam radiation. Charts were reviewed for all patients, and all living patients were contacted by phone. National Cancer Institute common toxicity scores for proctitis were assigned to all patients. Actuarial risk of late toxicity was calculated by the Kaplan-Meier method. Statistical analysis was performed using SPSS software. Follow-up ranged from 3 to 126 months (median, 48.5 months; mean, 56.8 months).
RESULTS: None of the patients experienced Grade 3 or 4 rectal toxicity. Four patients experienced Grade 2 late rectal toxicity. The 5-year actuarial freedom from developing late Grade 2 rectal toxicity was 81%. At a median follow-up of 48.5 months, 23 patients were alive and had no evidence of disease with a median prostate-specific antigen for the sample of 0.1 ng/mL (range,
CONCLUSIONS: Prostate brachytherapy is well tolerated in patients with a history of controlled IBD. Therefore, brachytherapy should be considered a viable therapeutic option in this patient population.
Published In/Presented At
Peters, C. A., Cesaretti, J. A., Stone, N. N., & Stock, R. G. (2006). Low-dose rate prostate brachytherapy is well tolerated in patients with a history of inflammatory bowel disease. International journal of radiation oncology, biology, physics, 66(2), 424–429. https://doi.org/10.1016/j.ijrobp.2006.05.027
Medicine and Health Sciences | Oncology
Department of Radiation Oncology