Distribution of 99mTc-1-thioglucose in rats: effect of administration route on pancreatic specificity.
Tissue distribution of 99mTc-1-thioglucose was studied in inbred albino Fisher rats. High levels of radioactivity were observed in the kidney with concurrent low pancreatic levels and pancreas/liver ratios of 0.4 following intravenous administration of the agent. High pancreatic concentration were observed with pancreas/liver ratios of 4.0 after intraperitoneal administrations. Future studies on pancreatic radiopharmaceuticals should avoid production of artificially high pancreatic values by intraperitoneal injection.
Published In/Presented At
Risch, V. R., Honda, T., Heindel, N. D., Emrich, J. L., & Brady, L. W. (1977). Distribution of 99mTc-1-thioglucose in rats: effect of administration route on pancreatic specificity. Radiology, 124(3), 837–838. https://doi.org/10.1148/124.3.837
Medicine and Health Sciences | Oncology
Department of Radiation Oncology