Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION).
Publication/Presentation Date
2-22-2022
Abstract
BACKGROUND AND HYPOTHESIS: Recently, two multicenter randomized controlled trials (RCT) failed to show a significantly beneficial effect of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). However, both trials suffered from equipoise issues which may have hindered the validity of the trial results. Therefore, additional RCT studies are needed to explore the potential benefit of EVT in patients presenting with BAO.
STUDY DESIGN: ATTENTION is an investigator-initiated, multicenter, prospective, randomized, controlled clinical trial with open-label treatment and blinded outcome assessment (PROBE) of EVT versus best medical management (BMM). The primary effect parameter is a modified Rankin Score of 0-3 at day 90.
DISCUSSION: ATTENTION will provide evidence for the efficacy and safety of EVT in stroke patients within 12 h after BAO.
TRIAL REGISTRATION: ClinicalTrials.gov NCT04751708.
First Page
17474930221077164
Last Page
17474930221077164
ISSN
1747-4949
Published In/Presented At
Tao, C., Li, R., Zhu, Y., Qun, S., Xu, P., Wang, L., Zhang, C., Liu, T., Song, J., Sun, W., Wang, G., Baxter, B., Qureshi, A., Liu, X., Nogueira, R. G., & Hu, W. (2022). Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION). International journal of stroke : official journal of the International Stroke Society, 17474930221077164. Advance online publication. https://doi.org/10.1177/17474930221077164
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
35102797
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article