Venous valvular assessment after retrograde catheterization.
PURPOSE: To determine whether retrograde passage of a coaxial infusion system (Mewissen-Katzen catheter and guide wire) into extremity veins with valves causes damage.
MATERIALS AND METHODS: Retrograde common femoral vein puncture and passage of an infusion wire-catheter system through the superficial femoral and popliteal veins of one leg were performed in five anesthetized pigs. Heparinized saline was then infused via the catheter and wire for approximately 8 hours. The pigs were then killed, and the femoropopliteal veins were removed from both legs of each pig and examined by a pathologist. The noncatheterized leg veins served as a control in each animal.
RESULTS: Valvular damage occurred in one of five pigs. This may have resulted from leg movement during catheter passage in this animal.
CONCLUSION: Retrograde passage of a catheter-guide-wire infusion system caused minimal to no damage to the venous valves of pigs. This suggests that human venous valves may be spared injury during catheter-directed venous thrombolysis. Further study of catheter manipulation in a model of deep venous thrombosis is needed.
Published In/Presented At
Jaffe, J. W., Newcomb, J. A., York, T., & Matulewicz, T. J. (1996). Venous valvular assessment after retrograde catheterization. Journal of vascular and interventional radiology : JVIR, 7(4), 595–597. https://doi.org/10.1016/s1051-0443(96)70811-4
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
Department of Radiology and Diagnostic Medical Imaging