F-18 FDG PET/CT for detection of malignant involvement of peripheral nerves: case series and literature review.
PURPOSE: To evaluate the role of positron emission tomography plus computed tomography (PET/CT) scans in detecting malignant involvement of the peripheral nerves (PNs).
MATERIAL AND METHODS: We retrospectively reviewed medical records of all PET/CT studies performed at The University of Texas MD Anderson Cancer Center between 2003 and 2009, and selected patients in whom F-18 fluorodeoxyglucose (FDG) PET/CT findings were suspicious for malignant involvement of the PNs. We identified 26 cases of suspected tumorous involvement of the PNs that was subsequently confirmed by either biopsy or clinical follow-up. We evaluated the value of PET/CT in diagnosing malignant involvement of the PNs.
RESULTS: Of the 26 patients, 12 had lymphoma, 10 had breast cancer, 2 had lung cancer, 1 had colon cancer, and 1 had melanoma. In 21 patients, magnetic resonance imaging (MRI) was performed, either for follow-up of the PET/CT finding or to find an explanation for symptoms. MRI confirmed the presence of disease in only 9 patients, was interpreted as normal in 7 patients, and was inconclusive in 5 patients. FDG PET/CT was able to differentiate an active tumor from post-treatment fibrosis and could assess response to therapy with a high degree of confidence.
CONCLUSIONS: Our results indicate that FDG PET/CT is helpful in diagnosing malignant involvement of the PNs, especially when findings from anatomic imaging (MRI or CT) are negative. In cases of known treated malignancy involving the PNs, follow-up by PET/CT has the advantage of high sensitivity for local recurrence.
Published In/Presented At
Bronstein, Y., Tummala, S., & Rohren, E. (2011). F-18 FDG PET/CT for detection of malignant involvement of peripheral nerves: case series and literature review. Clinical nuclear medicine, 36(2), 96–100. https://doi.org/10.1097/RLU.0b013e318203bb0e
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
Department of Radiology and Diagnostic Medical Imaging