Evidence for the association of cytomegalovirus with carcinoma of the prostate.
A human genital isolate of cytomegalovirus is shown to have transformed human embryonic lung cells in vitro. These cells produce tumors when injected into athymic nude mice. Two cell lines derived from tissue from human prostatic carcinoma have survived more than 20 passages in vitro and demonstrate cytomegalovirus-specific membrane antigen. Significant humoral antibody titers against cytomegalovirus have been demonstrated. Cell-mediated lymphocytotoxicity against these transformed cells has been demonstrated in patients with urinary tract tumors. This evidence indicates that an association between cytomegalovirus and human prostatic cancer may be more than coincidental.
Published In/Presented At
Sanford, E. J., Geder, L., Laychock, A., Rohner, T. J., Jr, & Rapp, F. (1977). Evidence for the association of cytomegalovirus with carcinoma of the prostate. The Journal of urology, 118(5), 789–792. https://doi.org/10.1016/s0022-5347(17)58194-x
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
Department of Radiology and Diagnostic Medical Imaging